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KMID : 0613820090190040462
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Journal of Life Science
2009 Volume.19 No. 4 p.462 ~ p.466
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Antioxidant and TNF-α Inducing Ability of Styela plicata Extracts
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Suh Hyun-Hyo
Lee Bo-Bae
Lee Seung-Cheol
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Abstract
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After preparing extracts from fresh Styela plicata using methanol, ethanol, acetone, and water, the antioxidant and tumor necrosis factor (TNF)-α inducing ability of the extracts were evaluated. Most of the extracts showed more than 50% inhibitory activity against malonedialdehyde formation, and methanol extract exhibited the highest activity with values of 59.3%. The water and acetone extracts contained glutathione contents of 18.5 and 12.3 μM, respectively, however, these were not detected in the other extracts. TNF-α inducing abilities of the extracts were determined with RAW 264.7 cells. The water extract increased TNF-α production with correlation to increase of the added amount. However, the other extracts could not induce TNF- α production in RAW 264.7 cells. The results indicated that the antioxidant activities of S. plicata extracts were different depending on extracting solvents, and the water extract showed significant TNF-α inducing activity.
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KEYWORD
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Antioxidant, immunostimulatory, Styela plicata, TNF-α
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